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| カタログ番号 | HF602014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ABCA1 Polyclonal Antibody (HF602014) is a rabbit polyclonal antibody detecting ABCA1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ABCA1 (Ser45-Glu271). | ||||||||
| ターゲット | ATP-binding cassette transporter 1, ATP-binding cassette sub-family A member 1, Phospholipid-transporting ATPase ABCA1, ABC-1, ABCA1, ATP-binding cassette 1, Cholesterol efflux regulatory protein, ABC1, CERP | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95477 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Phospholipid-transporting ATPase ABCA1 is a ~254 kDa protein. Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs. Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain. 1. Quazi, F. et al. (2013) The Journal of biological chemistry 288, 34414-26. PMID: 24097981 2. Segrest, JP. et al. (2022) Nature communications 13, 4812. PMID: 35974019 3. Krimbou, L. et al. (2004) Journal of lipid research 45, 839-48. PMID: 14754908 4. Marcil, M. et al. (1999) Lancet (London, England) 354, 1341-6. PMID: 10533863 | ||||||||
| 注意事項 | For research use only. |
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