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| カタログ番号 | HV604014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ABCA3 (Asp1358-Phe1635). | ||||||||
| ターゲット | ABCA3, ATP-binding cassette sub-family A member 3, Phospholipid-transporting ATPase ABCA3, ABC3, ATP-binding cassette 3, ATP-binding cassette transporter 3, ABC-C transporter, Xenobiotic-transporting ATPase ABCA3 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q99758 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Phospholipid-transporting ATPase ABCA3 is a ~191 kDa protein. Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant. Transports preferentially phosphatidylcholine containing short acyl chains. In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity. 1. Matsumura, Y. et al. (2006) The Journal of biological chemistry 281, 34503-14. PMID: 16959783 2. Matsumura, Y. et al. (2007) FEBS letters 581, 3139-44. PMID: 17574245 3. Wittmann, T. et al. (2016) Pediatric pulmonology 51, 1284-1294. PMID: 27177387 4. Höppner, S. et al. (2017) Biochimica et biophysica acta. Molecular cell research 1864, 2330-2335. PMID: 28887056 5. Li, Y. et al. (2019) Biochimica et biophysica acta. Molecular and cell biology of lipids 1864, 158516. PMID: 31473345 6. Zarbock, R. et al. (2015) Biochimica et biophysica acta 1851, 987-95. PMID: 25817392 7. Dohmen, LC. et al. (2016) The Journal of biological chemistry 291, 9638-47. PMID: 26903515 | ||||||||
| 注意事項 | For research use only. |
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