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| カタログ番号 | HT434014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ABCC4 Polyclonal Antibody (HT434014) is a rabbit polyclonal antibody detecting ABCC4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ABCC4 (Ile1041-Gln1274). | ||||||||
| ターゲット | MOAT-B, MOATB, Multi-specific organic anion transporter B, ATP-binding cassette sub-family C member 4, Multidrug resistance-associated protein 4, MRP4, ABCC4, MRP/cMOAT-related ABC transporter | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15439 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ATP-binding cassette sub-family C member 4 (ABCC4) is a ~149 kDa protein. ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). 1. van Aubel, RAMH. et al. (2002) Journal of the American Society of Nephrology : JASN 13, 595-603. PMID: 11856762 2. Zelcer, N. et al. (2003) The Biochemical journal 371, 361-7. PMID: 12523936 3. Sauna, ZE. et al. (2004) The Journal of biological chemistry 279, 48855-64. PMID: 15364914 4. Zhu, Y. et al. (2024) FEBS letters 598, 1967-1980. PMID: 38886124 5. Xie, Z. et al. (2025) Cell reports 44, 115466. PMID: 40138312 6. Reid, G. et al. (2003) Proceedings of the National Academy of Sciences of the United States of America 100, 9244-9. PMID: 12835412 7. Rius, M. et al. (2003) Hepatology (Baltimore, Md.) 38, 374-84. PMID: 12883481 | ||||||||
| 注意事項 | For research use only. |
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