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| カタログ番号 | HT035014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ABCD4 Polyclonal Antibody (HT035014) is a rabbit polyclonal antibody detecting ABCD4 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ABCD4 (Leu356-Glu606). | ||||||||
| ターゲット | ATP-binding cassette sub-family D member 4, ABCD4, PXMP1-L, PMP70-related protein, Peroxisomal membrane protein 1-like, P70R, PMP69, Peroxisomal membrane protein 69, PXMP1L, Lysosomal cobalamin transporter ABCD4 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O14678 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Lysosomal cobalamin transporter ABCD4 is a ~68 kDa protein. Lysosomal membrane protein that transports cobalamin (Vitamin B12) from the lysosomal lumen to the cytosol in an ATP-dependent manner. Targeted by LMBRD1 lysosomal chaperone from the endoplasmic reticulum to the lysosomal membrane. Then forms a complex with lysosomal chaperone LMBRD1 and cytosolic MMACHC to transport cobalamin across the lysosomal membrane. 1. Coelho, D. et al. (2012) Nature genetics 44, 1152-5. PMID: 22922874 2. Fettelschoss, V. et al. (2017) The Journal of biological chemistry 292, 11980-11991. PMID: 28572511 3. Xu, D. et al. (2019) Cell research 29, 1039-1041. PMID: 31467407 4. Kitai, K. et al. (2021) The Journal of biological chemistry 296, 100654. PMID: 33845046 5. Kawaguchi, K. et al. (2016) Scientific reports 6, 30183. PMID: 27456980 6. Deme, JC. et al. (2014) Molecular membrane biology 31, 250-61. PMID: 25535791 | ||||||||
| 注意事項 | For research use only. |
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