Anti-Human ADCYAP1/PACAP Polyclonal Antibody (HB716014)

Name: Anti-Human ADCYAP1/PACAP Polyclonal Antibody
Brand: abinScience
SKU: HB716014
Price: 168 USD
Availability: InStock

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100ug

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SDS

Aperçu

Numéro de catalogue

HB716014

Description

Anti-Human ADCYAP1/PACAP Polyclonal Antibody (HB716014) is a rabbit polyclonal antibody detecting ADCYAP1/PACAP in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human ADCYAP1 (Ile17-Leu176).

Cible

Pituitary adenylate cyclase-activating polypeptide, ADCYAP1, PACAP, PACAP-38, PACAP38, PACAP-27, PACAP27, PRP-48

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Purified by antigen affinity column.

Numéro d'accès

P18509

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) is a ~18 kDa protein. PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells.

1. Inooka, H. et al. (2001) Nature structural biology 8, 161-5. PMID: 11175907

2. Emery, AC. et al. (2013) Science signaling 6, ra51. PMID: 23800469

3. Wang, J. et al. (2020) Cell research 30, 436-445. PMID: 32047270

4. Piper, SJ. et al. (2022) Nature communications 13, 7013. PMID: 36385145

Note

For research use only.

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