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| カタログ番号 | HB933014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-AKT2 Polyclonal Antibody (HB933014) is a rabbit polyclonal antibody detecting AKT2 in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human AKT2 (Met1-Lys146). | ||||||||
| ターゲット | PKB beta, Protein kinase Akt-2, AKT2, Protein kinase B beta, RAC-beta serine/threonine-protein kinase, RAC-PK-beta | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P31751 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | RAC-beta serine/threonine-protein kinase (AKT2) is a ~55 kDa protein. Serine/threonine kinase closely related to AKT1 and AKT3. All 3 enzymes, AKT1, AKT2 and AKT3, are collectively known as AKT kinase. AKT regulates many processes including metabolism, proliferation, cell survival, growth and angiogenesis, through the phosphorylation of a range of downstream substrates. Over 100 substrates have been reported so far, although for most of them, the precise AKT kinase catalyzing the reaction was not specified. AKT regulates glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. 1. Heron-Milhavet, L. et al. (2011) Histology and histopathology 26, 651-62. PMID: 21432781 2. Hers, I. et al. (2011) Cellular signalling 23, 1515-27. PMID: 21620960 3. Walia, V. et al. (2019) Developmental cell 50, 229-246.e7. PMID: 31204173 4. Wolf, A. et al. (2013) Journal of cell science 126, 1832-44. PMID: 23444369 | ||||||||
| 注意事項 | For research use only. |
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