

| Numéro de catalogue | HY240014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-ALDOB Polyclonal Antibody (HY240014) is a rabbit polyclonal antibody detecting ALDOB in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| Reactivité des espèces | Human, Mouse, Rat | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human ALDOB (Thr9-Tyr364). | ||||||||
| Cible | ALDOB, Liver-type aldolase, Fructose-bisphosphate aldolase B, ALDB | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P05062 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Fructose-bisphosphate aldolase B (ALDOB) is a ~39 kDa protein. Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde. Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check. 1. Santamaria, R. et al. (2000) The Biochemical journal 350 Pt 3, 823-8. PMID: 10970798 2. Sánchez-Gutiérrez, JC. et al. (2002) Journal of medical genetics 39, e56. PMID: 12205126 3. Esposito, G. et al. (2010) Human mutation 31, 1294-303. PMID: 20848650 4. Li, M. et al. (2020) Nature cancer 1, 735-747. PMID: 35122041 | ||||||||
| Note | For research use only. |
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