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| カタログ番号 | HY240014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ALDOB Polyclonal Antibody (HY240014) is a rabbit polyclonal antibody detecting ALDOB in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ALDOB (Thr9-Tyr364). | ||||||||
| ターゲット | ALDOB, Liver-type aldolase, Fructose-bisphosphate aldolase B, ALDB | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P05062 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Fructose-bisphosphate aldolase B (ALDOB) is a ~39 kDa protein. Catalyzes the aldol cleavage of fructose 1,6-biphosphate to form two triosephosphates dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate in glycolysis as well as the reverse stereospecific aldol addition reaction in gluconeogenesis. In fructolysis, metabolizes fructose 1-phosphate derived from the phosphorylation of dietary fructose by fructokinase into dihydroxyacetone phosphate and D-glyceraldehyde. Acts as an adapter independently of its enzymatic activity, exerts a tumor suppressor role by stabilizing the ternary complex with G6PD and TP53 to inhibit G6PD activity and keep oxidative pentose phosphate metabolism in check. 1. Santamaria, R. et al. (2000) The Biochemical journal 350 Pt 3, 823-8. PMID: 10970798 2. Sánchez-Gutiérrez, JC. et al. (2002) Journal of medical genetics 39, e56. PMID: 12205126 3. Esposito, G. et al. (2010) Human mutation 31, 1294-303. PMID: 20848650 4. Li, M. et al. (2020) Nature cancer 1, 735-747. PMID: 35122041 | ||||||||
| 注意事項 | For research use only. |
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