Anti-Human Angiopoietin-2 Polyclonal Antibody (HT073014)

Name: Anti-Human Angiopoietin-2 Polyclonal Antibody
Brand: abinScience
SKU: HT073014
Price: 168 USD
Availability: InStock

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Vista general

Número de catálogo

HT073014

Descripción

Anti-ANGPT2 Polyclonal Antibody (HT073014) is a rabbit polyclonal antibody detecting ANGPT2 in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human ANGPT2 (Lys24-Leu165).

Objetivo

ANG-2, ANGPT2, Angiopoietin-2

Nivel de endotoxinas

Please contact with the lab for this information.

Purificación

Purified by antigen affinity column.

Número de acceso

O15123

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Angiopoietin-2 (ANGPT2/ANG-2) is a ~56 kDa protein. Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis.

1. Lee, HJ. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1200-8. PMID: 15284220

2. Yacyshyn, OK. et al. (2009) Angiogenesis 12, 25-33. PMID: 19116766

3. Yuan, HT. et al. (2009) Molecular and cellular biology 29, 2011-22. PMID: 19223473

4. Maisonpierre, PC. et al. (1997) Science (New York, N.Y.) 277, 55-60. PMID: 9204896

5. Leppänen, VM. et al. (2020) Science translational medicine 12. PMID: 32908006

Nota

For research use only.

Imágenes

Referencias

Datasheet