Anti-Human Angiopoietin-2 Reference Antibody (AT006, RUO) (HT073056)

Name: Anti-Human Angiopoietin-2 Reference Antibody (AT006, RUO)
Brand: abinScience
SKU: HT073056
Price: 370 USD
Availability: InStock

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Overview

Catalog No.	HT073056
Description	Anti-Human ANGPT2 (AT006) (HT073056) is a research-grade recombinant antibody targeting ANG-2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG
Clone ID	AT006
Expression system	Mammalian cells
Clonality	Monoclonal
Target	ANG-2, ANGPT2, Angiopoietin-2
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O15123
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	AT006
Background	Angiopoietin-2 (ANGPT2/ANG-2) is a ~56 kDa protein. Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis. 1. Lee, HJ. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1200-8. PMID: 15284220 2. Yacyshyn, OK. et al. (2009) Angiogenesis 12, 25-33. PMID: 19116766 3. Yuan, HT. et al. (2009) Molecular and cellular biology 29, 2011-22. PMID: 19223473 4. Maisonpierre, PC. et al. (1997) Science (New York, N.Y.) 277, 55-60. PMID: 9204896 5. Leppänen, VM. et al. (2020) Science translational medicine 12. PMID: 32908006
Note	For research use only. Not suitable for clinical or therapeutic use.