Anti-Human Angiopoietin-2 Polyclonal Antibody (HT073014)

Name: Anti-Human Angiopoietin-2 Polyclonal Antibody
Brand: abinScience
SKU: HT073014
Price: 168 USD
Availability: InStock

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Aperçu

Numéro de catalogue

HT073014

Description

Anti-ANGPT2 Polyclonal Antibody (HT073014) is a rabbit polyclonal antibody detecting ANGPT2 in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human ANGPT2 (Lys24-Leu165).

Cible

ANG-2, ANGPT2, Angiopoietin-2

Niveau d'endotoxines

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Numéro d'accès

O15123

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Angiopoietin-2 (ANGPT2/ANG-2) is a ~56 kDa protein. Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal. Involved in the regulation of lymphangiogenesis.

1. Lee, HJ. et al. (2004) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 18, 1200-8. PMID: 15284220

2. Yacyshyn, OK. et al. (2009) Angiogenesis 12, 25-33. PMID: 19116766

3. Yuan, HT. et al. (2009) Molecular and cellular biology 29, 2011-22. PMID: 19223473

4. Maisonpierre, PC. et al. (1997) Science (New York, N.Y.) 277, 55-60. PMID: 9204896

5. Leppänen, VM. et al. (2020) Science translational medicine 12. PMID: 32908006

Note

For research use only.

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