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Anti-ANO6 Polyclonal Antibody (HS838014)

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Vista general
Número de catálogoHS838014
Descripción
Anti-ANO6 Polyclonal Antibody (HS838014) is a rabbit polyclonal antibody detecting ANO6 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human ANO6 (Ala744-Asn824).
Objetivo SCAN channel, ANO6, TMEM16F, Small-conductance calcium-activated nonselective cation channel, Transmembrane protein 16F, Anoctamin-6
Purificación Purified by antigen affinity column.
Número de acceso Q4KMQ2
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Anoctamin-6 (ANO6/TMEM16F) is a ~106 kDa protein. Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.

1. Schreiber, R. et al. (2010) The Journal of biological chemistry 285, 7838-45. PMID: 20056604
2. Suzuki, J. et al. (2010) Nature 468, 834-8. PMID: 21107324
3. Kunzelmann, K. et al. (2012) Experimental physiology 97, 184-92. PMID: 21908539
4. Martins, JR. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 18168-72. PMID: 22006324
5. Tian, Y. et al. (2012) Journal of cell science 125, 4991-8. PMID: 22946059
Nota For research use only.
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Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-ANO6 Polyclonal Antibody

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