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Anti-ANO6 Polyclonal Antibody (HS838014)

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Aperçu
Numéro de catalogueHS838014
Description
Anti-ANO6 Polyclonal Antibody (HS838014) is a rabbit polyclonal antibody detecting ANO6 in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactivité des espècesHuman
ApplicationsELISA, IHC, WB
Espèce hôteRabbit
ClonalitéPolyclonal
IsotypeIgG
Immunogène E. coli - derived recombinant Human ANO6 (Ala744-Asn824).
Cible SCAN channel, ANO6, TMEM16F, Small-conductance calcium-activated nonselective cation channel, Transmembrane protein 16F, Anoctamin-6
Purification Purified by antigen affinity column.
Numéro d'accès Q4KMQ2
Forme Liquid
Tampon de stockage 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Informations d'utilisation du produit
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Stabilité et stockage Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte

Anoctamin-6 (ANO6/TMEM16F) is a ~106 kDa protein. Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.

1. Schreiber, R. et al. (2010) The Journal of biological chemistry 285, 7838-45. PMID: 20056604
2. Suzuki, J. et al. (2010) Nature 468, 834-8. PMID: 21107324
3. Kunzelmann, K. et al. (2012) Experimental physiology 97, 184-92. PMID: 21908539
4. Martins, JR. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 18168-72. PMID: 22006324
5. Tian, Y. et al. (2012) Journal of cell science 125, 4991-8. PMID: 22946059
Note For research use only.
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-ANO6 Polyclonal Antibody

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