

| Каталожный номер | HS838014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-ANO6 Polyclonal Antibody (HS838014) is a rabbit polyclonal antibody detecting ANO6 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human ANO6 (Ala744-Asn824). | ||||||||
| Цель | SCAN channel, ANO6, TMEM16F, Small-conductance calcium-activated nonselective cation channel, Transmembrane protein 16F, Anoctamin-6 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q4KMQ2 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Anoctamin-6 (ANO6/TMEM16F) is a ~106 kDa protein. Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes. 1. Schreiber, R. et al. (2010) The Journal of biological chemistry 285, 7838-45. PMID: 20056604 2. Suzuki, J. et al. (2010) Nature 468, 834-8. PMID: 21107324 3. Kunzelmann, K. et al. (2012) Experimental physiology 97, 184-92. PMID: 21908539 4. Martins, JR. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 18168-72. PMID: 22006324 5. Tian, Y. et al. (2012) Journal of cell science 125, 4991-8. PMID: 22946059 | ||||||||
| Примечание | For research use only. |
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