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| カタログ番号 | HW663014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-ANP32A Polyclonal Antibody (HW663014) is a rabbit polyclonal antibody detecting ANP32A in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Bovine.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human ANP32A (Glu2-Asp175). | ||||||||
| ターゲット | pp32, Putative HLA-DR-associated protein I, MAPM, ANP32A, C15orf1, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Mapmodulin, LANP, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A, PHAPI, Leucine-rich acidic nuclear protein, Acidic nuclear phosphoprotein pp32, PHAP1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P39687 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) is a ~28 kDa protein. Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition. 1. Brody, JR. et al. (1999) The Journal of biological chemistry 274, 20053-5. PMID: 10400610 2. Bai, J. et al. (2001) Oncogene 20, 2153-60. PMID: 11360199 3. Fan, Z. et al. (2006) Cell death and differentiation 13, 1485-94. PMID: 16341127 4. Kim, HE. et al. (2008) Molecular cell 30, 239-47. PMID: 18439902 5. Seo, SB. et al. (2002) The Journal of biological chemistry 277, 14005-10. PMID: 11830591 6. Mazroui, R. et al. (2008) The Journal of cell biology 180, 113-27. PMID: 18180367 7. Tsujio, I. et al. (2005) FEBS letters 579, 363-72. PMID: 15642345 8. Cvetanovic, M. et al. (2007) EMBO reports 8, 671-7. PMID: 17557114 | ||||||||
| 注意事項 | For research use only. |
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