Anti-ANP32A Polyclonal Antibody (HW663014)

Name: Anti-ANP32A Polyclonal Antibody
Brand: abinScience
SKU: HW663014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HW663014

Описание

Anti-ANP32A Polyclonal Antibody (HW663014) is a rabbit polyclonal antibody detecting ANP32A in ELISA, IHC, WB. Suitable for Human, Mouse, Dog, Rat, and Bovine.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human ANP32A (Glu2-Asp175).

Цель

pp32, Putative HLA-DR-associated protein I, MAPM, ANP32A, C15orf1, Acidic leucine-rich nuclear phosphoprotein 32 family member A, Mapmodulin, LANP, Potent heat-stable protein phosphatase 2A inhibitor I1PP2A, PHAPI, Leucine-rich acidic nuclear protein, Acidic nuclear phosphoprotein pp32, PHAP1

Очистка

Purified by antigen affinity column.

Номер доступа

P39687

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) is a ~28 kDa protein. Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition.

1. Brody, JR. et al. (1999) The Journal of biological chemistry 274, 20053-5. PMID: 10400610

2. Bai, J. et al. (2001) Oncogene 20, 2153-60. PMID: 11360199

3. Fan, Z. et al. (2006) Cell death and differentiation 13, 1485-94. PMID: 16341127

4. Kim, HE. et al. (2008) Molecular cell 30, 239-47. PMID: 18439902

5. Seo, SB. et al. (2002) The Journal of biological chemistry 277, 14005-10. PMID: 11830591

6. Mazroui, R. et al. (2008) The Journal of cell biology 180, 113-27. PMID: 18180367

7. Tsujio, I. et al. (2005) FEBS letters 579, 363-72. PMID: 15642345

8. Cvetanovic, M. et al. (2007) EMBO reports 8, 671-7. PMID: 17557114

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-ANP32A Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Mass

Concentration

Volume

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g/mol

Formula

C₁ × V₁ = C₂ × V₂

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Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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