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| カタログ番号 | HT209014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human BCAT2 (Ala107-Val392). | ||||||||
| ターゲット | BCT2, BCAT2, BCAT(m), BCATM, Placental protein 18, Branched-chain-amino-acid aminotransferase, mitochondrial, PP18, ECA40 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15382 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) is a ~44 kDa protein. Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. Branched chain amino acid catabolism plays a role in adipocyte differentiation by providing lipogenic acetyl-CoA pools in differentiated adipocytes. Mechanistically, acetyl-CoA derived from branched chain amino acid catabolism is used by EP300/p300 to acetylate and inhibit PRDM16, thereby preventing adipose tissue browning. May also function as a transporter of branched chain alpha-keto acids. 1. Yennawar, NH. et al. (2006) The Journal of biological chemistry 281, 39660-71. PMID: 17050531 2. Wang, XL. et al. (2015) Journal of inherited metabolic disease 38, 855-61. PMID: 25653144 3. Eden, A. et al. (1996) The Journal of biological chemistry 271, 20242-5. PMID: 8702755 | ||||||||
| 参考文献 | 1. Lei Zhao, et al. Design, screening and biological evaluation of novel fatty acid chain-modified oxyntomodulin-based derivatives with prolonged glucose-lowering ability and potent anti-obesity effects. Org Biomol Chem. 2019, 17, 33. [HT209014] | ||||||||
| 注意事項 | For research use only. |
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