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| カタログ番号 | HY023014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-BCR Polyclonal Antibody (HY023014) is a rabbit polyclonal antibody detecting BCR in ELISA, IHC, WB. Suitable for Human, Mouse, and Rat.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human BCR (Lys174-Asp331). | ||||||||
| ターゲット | Renal carcinoma antigen NY-REN-26, BCR1, BCR, D22S11, Breakpoint cluster region protein | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P11274 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Breakpoint cluster region protein (BCR) is a ~142 kDa protein. Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. 1. Cho, YJ. et al. (2007) Molecular and cellular biology 27, 899-911. PMID: 17116687 2. Diekmann, D. et al. (1991) Nature 351, 400-2. PMID: 1903516 3. Chuang, TH. et al. (1995) Proceedings of the National Academy of Sciences of the United States of America 92, 10282-6. PMID: 7479768 4. Dubash, AD. et al. (2013) The Journal of cell biology 202, 653-66. PMID: 23940119 5. Maru, Y. et al. (1991) Cell 67, 459-68. PMID: 1657398 | ||||||||
| 注意事項 | For research use only. |
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