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| カタログ番号 | HY406014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-BMP3/Osteogenin Polyclonal Antibody (HY406014) is a rabbit polyclonal antibody detecting Osteogenin in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Xenopus laevis.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human BMP3/Osteogenin (Gln363-Arg472). | ||||||||
| ターゲット | BMP-3, Bone morphogenetic protein 3A, Osteogenin, BMP-3A, Bone morphogenetic protein 3, BMP3, BMP3A | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P12645 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Bone morphogenetic protein 3 (BMP3/Osteogenin) is a ~53 kDa protein. Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways. 1. Daluiski, A. et al. (2001) Nature genetics 27, 84-8. PMID: 11138004 2. Kang, Q. et al. (2004) Gene therapy 11, 1312-20. PMID: 15269709 3. Wen, J. et al. (2019) Journal of experimental & clinical cancer research : CR 38, 428. PMID: 31665064 | ||||||||
| 注意事項 | For research use only. |
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