Human BMP3/Osteogenin Recombinant Protein (N-His) (HY406012)

Name: Human BMP3/Osteogenin Recombinant Protein (N-His)
Brand: abinScience
SKU: HY406012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HY406012
Description	Recombinant Human BMP3/Osteogenin Protein, N-His (HY406012) expressed in E. coli, spanning Gln363-Arg472. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Expression system	E. coli
Accession	P12645
Protein length	Gln363-Arg472
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Predicted molecular weight	14.7 kDa
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	BMP-3, Bone morphogenetic protein 3A, Osteogenin, BMP-3A, Bone morphogenetic protein 3, BMP3, BMP3A
Background	Bone morphogenetic protein 3 (BMP3/Osteogenin) is a ~53 kDa protein. Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways. 1. Daluiski, A. et al. (2001) Nature genetics 27, 84-8. PMID: 11138004 2. Kang, Q. et al. (2004) Gene therapy 11, 1312-20. PMID: 15269709 3. Wen, J. et al. (2019) Journal of experimental & clinical cancer research : CR 38, 428. PMID: 31665064
Note	For research use only.

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SDS-PAGE for Recombinant Human BMP3/Osteogenin Protein, N-His

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Datasheet

Human BMP3/Osteogenin Recombinant Protein (N-His).pdf

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Human BMP3/Osteogenin Recombinant Protein (N-His) (HY406012)

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