Anti-BMP3/Osteogenin Polyclonal Antibody (HY406014)

Name: Anti-BMP3/Osteogenin Polyclonal Antibody
Brand: abinScience
SKU: HY406014
Price: 168 USD
Availability: InStock

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Datasheet
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Overview

Catalog No.

HY406014

Description

Anti-BMP3/Osteogenin Polyclonal Antibody (HY406014) is a rabbit polyclonal antibody detecting Osteogenin in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Xenopus laevis.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human BMP3/Osteogenin (Gln363-Arg472).

Target

BMP-3, Bone morphogenetic protein 3A, Osteogenin, BMP-3A, Bone morphogenetic protein 3, BMP3, BMP3A

Purification

Purified by antigen affinity column.

Accession

P12645

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Bone morphogenetic protein 3 (BMP3/Osteogenin) is a ~53 kDa protein. Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways.

1. Daluiski, A. et al. (2001) Nature genetics 27, 84-8. PMID: 11138004

2. Kang, Q. et al. (2004) Gene therapy 11, 1312-20. PMID: 15269709

3. Wen, J. et al. (2019) Journal of experimental & clinical cancer research : CR 38, 428. PMID: 31665064

Note

For research use only.

Images

References

Datasheet

Anti-BMP3/Osteogenin Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-BMP3/Osteogenin Polyclonal Antibody (HY406014)

Overview

Images

References

Datasheet

SDS

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