Anti-Human BMP-4 Polyclonal Antibody (HY569014)

Name: Anti-Human BMP-4 Polyclonal Antibody
Brand: abinScience
SKU: HY569014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HY569014

Description

Anti-BMP4 Polyclonal Antibody (HY569014) is a rabbit polyclonal antibody detecting BMP4 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Dama dama.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human BMP4 (Ala24-Arg408).

Cible

BMP2B, BMP-2B, DVR4, Bone morphogenetic protein 4, BMP-4, BMP4, Bone morphogenetic protein 2B

Niveau d'endotoxines

Please contact with the lab for this information.

Pureté

>95% as determined by SDS-PAGE.

Purification

Purified by antigen affinity column.

Numéro d'accès

P12644

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Bone morphogenetic protein 4 (BMP4) is a ~46 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes.

1. Rezzola, S. et al. (2019) Angiogenesis 22, 521-533. PMID: 31363885

2. Rege, J. et al. (2015) Endocrinology 156, 2530-40. PMID: 25868050

3. ten Dijke, P. et al. (1994) The Journal of biological chemistry 269, 16985-8. PMID: 8006002

4. Jin, X. et al. (2017) Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 44, 1616-1628. PMID: 29212066

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human BMP-4 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

Anticorps

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