Anti-Human BMP4 Recombinant Antibody (SAA0424) (HY569107)

Name: Anti-Human BMP4 Recombinant Antibody (SAA0424)
Brand: abinScience
SKU: HY569107
Price: 196 USD
Availability: InStock

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Overview

Catalog No.	HY569107
Species reactivity	Human
Applications	ELISA, FCM
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	SAA0424
Clonality	Monoclonal
Target	BMP2B, BMP-2B, DVR4, Bone morphogenetic protein 4, BMP-4, BMP4, Bone morphogenetic protein 2B
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P12644
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.09% Sodium azide. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Bone morphogenetic protein 4 (BMP4) is a ~46 kDa protein. Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. 1. Rezzola, S. et al. (2019) Angiogenesis 22, 521-533. PMID: 31363885 2. Rege, J. et al. (2015) Endocrinology 156, 2530-40. PMID: 25868050 3. ten Dijke, P. et al. (1994) The Journal of biological chemistry 269, 16985-8. PMID: 8006002 4. Jin, X. et al. (2017) Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 44, 1616-1628. PMID: 29212066
Note	For research use only.

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Datasheet

Anti-Human BMP4 Recombinant Antibody (SAA0424).pdf

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Anti-Human BMP4 Recombinant Antibody (SAA0424) (HY569107)

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