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| カタログ番号 | HC650014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-BMPR2 Polyclonal Antibody (HC650014) is a rabbit polyclonal antibody detecting BMPR2 in ELISA, IHC, WB. Suitable for Human and Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human BMPR2 (Ser27-Thr150). | ||||||||
| ターゲット | BMP type II receptor, BMPR-II, Bone morphogenetic protein receptor type II, Bone morphogenetic protein receptor type-2, BMPR2, PPH1, BMP type-2 receptor, BMPR-2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q13873 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Bone morphogenetic protein receptor type-2 (BMPR2) is a ~115 kDa protein. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Can also mediate signaling through the activation of the p38MAPK cascade. Binds to BMP7, BMP2 and, less efficiently, BMP4. Binding is weak but enhanced by the presence of type I receptors for BMPs. 1. Rudarakanchana, N. et al. (2002) Human molecular genetics 11, 1517-25. PMID: 12045205 2. Rejon, CA. et al. (2013) Cellular signalling 25, 2717-26. PMID: 24018044 | ||||||||
| 注意事項 | For research use only. |
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