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| カタログ番号 | JN968014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 種反応性 | Bordetella pertussis | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Bordetella pertussis ptxA/PTXS (Asp35-Phe269). | ||||||||
| ターゲット | Pertussis toxin subunit 1, PTX S1, Islet-activating protein S1, IAP S1, NAD-dependent ADP-ribosyltransferase, 2.4.2.-, ptxA, BP3783 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P04977 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Pertussis toxin subunit 1 (ptxA/PTXS1) is a ~29 kDa protein. S1 is an NAD-dependent ADP-ribosyltransferase, which plays a crucial role in the pathogenesis of B.pertussis causing disruption of normal host cellular regulation. It catalyzes the ADP-ribosylation of a cysteine in the alpha subunit of host heterotrimeric G proteins. In the absence of G proteins it also catalyzes the cleavage of NAD(+) into ADP-ribose and nicotinamide. It irreversibly uncouples the G-alpha GTP-binding proteins from their membrane receptors. | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-PT polyclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant Bordetella pertussis ptxA/PTXS1 (Catalog No: JN968012)
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