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| カタログ番号 | HC372014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-C1QBP Polyclonal Antibody (HC372014) is a rabbit polyclonal antibody detecting C1QBP in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human C1QBP (Thr76-Gln282). | ||||||||
| ターゲット | Hyaluronan-binding protein 1, SF2AP32, C1QBP, gC1q-R protein, SF2P32, Glycoprotein gC1qBP, Complement component 1 Q subcomponent-binding protein, mitochondrial, ASF/SF2-associated protein p32, GC1QBP, HABP1, p33, C1qBP, Mitochondrial matrix protein p32 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q07021 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) is a ~31 kDa protein. Multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. At the cell surface is thought to act as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades. Putative receptor for C1q; specifically binds to the globular 'heads' of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. In complex with cytokeratin-1/KRT1 is a high affinity receptor for kininogen-1/HMWK. Can also bind other plasma proteins, such as coagulation factor XII leading to its autoactivation. 1. Petersen-Mahrt, SK. et al. (1999) The EMBO journal 18, 1014-24. PMID: 10022843 2. Joseph, K. et al. (1999) Clinical immunology (Orlando, Fla.) 92, 246-55. PMID: 10479529 3. Nguyen, T. et al. (2000) Infection and immunity 68, 2061-8. PMID: 10722602 4. Kittlesen, DJ. et al. (2000) The Journal of clinical investigation 106, 1239-49. PMID: 11086025 5. Feng, X. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 168, 2441-8. PMID: 11859136 6. Chattopadhyay, C. et al. (2004) Nucleic acids research 32, 3632-41. PMID: 15243141 7. Vegh, Z. et al. (2006) Molecular immunology 43, 1402-7. PMID: 16140380 8. Waggoner, SN. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 175, 4706-14. PMID: 16177118 9. Waggoner, SN. et al. (2007) Journal of leukocyte biology 82, 1407-19. PMID: 17881511 10. Huang, L. et al. (2008) Investigative ophthalmology & visual science 49, 5243-9. PMID: 18676636 | ||||||||
| 注意事項 | For research use only. |
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