Anti-CD107b/LAMP2 Polyclonal Antibody (HY293014)

Name: Anti-CD107b/LAMP2 Polyclonal Antibody
Brand: abinScience
SKU: HY293014
Price: 168 USD
Availability: InStock

Datasheet Compartir producto Copiar información

Precio(USD):

Especificación:

50ug
100ug

Número:

Contáctenos

Vista general
Imágenes
Referencias
Datasheet
SDS

Vista general

Número de catálogo

HY293014

Descripción

Anti-CD107b/LAMP2 Polyclonal Antibody (HY293014) is a rabbit polyclonal antibody detecting CD107b in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human CD107b/LAMP2 (Leu29-Gln366).

Objetivo

LGP-96, CD107b, LAMP2, CD107 antigen-like family member B, Lysosome-associated membrane glycoprotein 2, Lysosome-associated membrane protein 2, LAMP-2

Purificación

Purified by antigen affinity column.

Número de acceso

P13473

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Lysosome-associated membrane glycoprotein 2 (CD107b/LAMP2) is a ~44 kDa protein. Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. Functions by binding target proteins, such as GAPDH, GPX4, NLRP3 and MLLT11, and targeting them for lysosomal degradation. In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2.

1. Cuervo, AM. et al. (2000) Journal of cell science 113 Pt 24, 4441-50. PMID: 11082038

2. Bandyopadhyay, U. et al. (2008) Molecular and cellular biology 28, 5747-63. PMID: 18644871

3. Li, P. et al. (2014) Experimental cell research 327, 48-56. PMID: 24880125

4. Hubert, V. et al. (2016) Biology open 5, 1516-1529. PMID: 27628032

5. Wang, L. et al. (2023) Molecular cell 83, 281-297.e10. PMID: 36586411

6. Zhang, J. et al. (2023) Molecular cell 83, 2524-2539.e7. PMID: 37390818

7. Cuervo, AM. et al. (1996) Science (New York, N.Y.) 273, 501-3. PMID: 8662539

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-CD107b/LAMP2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo