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| カタログ番号 | HY293014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CD107b/LAMP2 Polyclonal Antibody (HY293014) is a rabbit polyclonal antibody detecting CD107b in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CD107b/LAMP2 (Leu29-Gln366). | ||||||||
| ターゲット | LGP-96, CD107b, LAMP2, CD107 antigen-like family member B, Lysosome-associated membrane glycoprotein 2, Lysosome-associated membrane protein 2, LAMP-2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P13473 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Lysosome-associated membrane glycoprotein 2 (CD107b/LAMP2) is a ~44 kDa protein. Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. Functions by binding target proteins, such as GAPDH, GPX4, NLRP3 and MLLT11, and targeting them for lysosomal degradation. In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2. 1. Cuervo, AM. et al. (2000) Journal of cell science 113 Pt 24, 4441-50. PMID: 11082038 2. Bandyopadhyay, U. et al. (2008) Molecular and cellular biology 28, 5747-63. PMID: 18644871 3. Li, P. et al. (2014) Experimental cell research 327, 48-56. PMID: 24880125 4. Hubert, V. et al. (2016) Biology open 5, 1516-1529. PMID: 27628032 5. Wang, L. et al. (2023) Molecular cell 83, 281-297.e10. PMID: 36586411 6. Zhang, J. et al. (2023) Molecular cell 83, 2524-2539.e7. PMID: 37390818 7. Cuervo, AM. et al. (1996) Science (New York, N.Y.) 273, 501-3. PMID: 8662539 | ||||||||
| 注意事項 | For research use only. |
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