Anti-CD107b/LAMP2 Polyclonal Antibody (HY293014)

Name: Anti-CD107b/LAMP2 Polyclonal Antibody
Brand: abinScience
SKU: HY293014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HY293014

Описание

Anti-CD107b/LAMP2 Polyclonal Antibody (HY293014) is a rabbit polyclonal antibody detecting CD107b in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human CD107b/LAMP2 (Leu29-Gln366).

Цель

LGP-96, CD107b, LAMP2, CD107 antigen-like family member B, Lysosome-associated membrane glycoprotein 2, Lysosome-associated membrane protein 2, LAMP-2

Очистка

Purified by antigen affinity column.

Номер доступа

P13473

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Lysosome-associated membrane glycoprotein 2 (CD107b/LAMP2) is a ~44 kDa protein. Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. Functions by binding target proteins, such as GAPDH, GPX4, NLRP3 and MLLT11, and targeting them for lysosomal degradation. In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2.

1. Cuervo, AM. et al. (2000) Journal of cell science 113 Pt 24, 4441-50. PMID: 11082038

2. Bandyopadhyay, U. et al. (2008) Molecular and cellular biology 28, 5747-63. PMID: 18644871

3. Li, P. et al. (2014) Experimental cell research 327, 48-56. PMID: 24880125

4. Hubert, V. et al. (2016) Biology open 5, 1516-1529. PMID: 27628032

5. Wang, L. et al. (2023) Molecular cell 83, 281-297.e10. PMID: 36586411

6. Zhang, J. et al. (2023) Molecular cell 83, 2524-2539.e7. PMID: 37390818

7. Cuervo, AM. et al. (1996) Science (New York, N.Y.) 273, 501-3. PMID: 8662539

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-CD107b/LAMP2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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