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Anti-Human IL-1 RI Polyclonal Antibody (HB791014)

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Vista general
Número de catálogoHB791014
Descripción
Anti-CD121a/IL1R1 Polyclonal Antibody (HB791014) is a rabbit polyclonal antibody detecting CD121a in ELISA, IHC, WB. Suitable for Human.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
Reactividad de especiesHuman
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human CD121a/IL1R1 (Asp21-Ile109).
Objetivo IL-1RT1, IL-1R-alpha, mIL-1R1, CD121a, IL-1R-1, sIL-1RI, IL1RT1, IL1R1, sIL-1R1, IL1R, CD121 antigen-like family member A, Interleukin-1 receptor type I, Interleukin-1 receptor alpha, mIL-1RI, IL1RA, IL-1RT-1, Interleukin-1 receptor type 1, p80
Purificación Purified by antigen affinity column.
Número de acceso P14778
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Interleukin-1 receptor type 1 (CD121a/IL1R1) is a ~65 kDa protein. Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.

1. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091
2. Wang, Y. et al. (2023) Immunity 56, 1485-1501.e7. PMID: 37315560
3. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Anti-Human IL-1 RI Polyclonal Antibody

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