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| カタログ番号 | HB896014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CD191/CCR1 Polyclonal Antibody (HB896014) is a rabbit polyclonal antibody detecting CD191 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CD191/CCR1 (Gln265-Leu281). | ||||||||
| ターゲット | CMKR1, SCYAR1, Macrophage inflammatory protein 1-alpha receptor, CMKBR1, MIP-1alpha-R, HM145, CC-CKR-1, RANTES-R, LD78 receptor, CCR-1, C-C chemokine receptor type 1, CCR1, CD191, C-C CKR-1 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P32246 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | C-C chemokine receptor type 1 (CD191/CCR1) is a ~41 kDa protein. Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4. Also mediates monocyte migration upon CXCL4 binding. 1. Tian, Y. et al. (2004) European journal of immunology 34, 785-795. PMID: 14991608 2. Berahovich, RD. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 174, 7341-51. PMID: 15905581 3. Wei, H. et al. (2024) Cellular signalling 117, 111122. PMID: 38417634 4. Fox, JM. et al. (2018) Scientific reports 8, 9466. PMID: 29930254 | ||||||||
| 注意事項 | For research use only. |
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