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Anti-Human CD191/CCR1 Recombinant Antibody (5908), APC (HB896137)

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Overview

Catalog No.	HB896137
Description	Anti-Human CD191/CCR1 Antibody (5908), APC [5908] (HB896137) is a mouse monoclonal antibody detecting CD191 in FCM. Suitable for Human. Highlights ●Flow Cytometry — Validated for flow cytometry applications. ●Fluorescent Label — Direct conjugate for streamlined workflows.
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	5908
Conjugation	APC
Clonality	Monoclonal
Target	CMKR1, SCYAR1, Macrophage inflammatory protein 1-alpha receptor, CMKBR1, MIP-1alpha-R, HM145, CC-CKR-1, RANTES-R, LD78 receptor, CCR-1, C-C chemokine receptor type 1, CCR1, CD191, C-C CKR-1
Endotoxin level	Please contact with the lab for this information.
Accession	P32246
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	C-C chemokine receptor type 1 (CD191/CCR1) is a ~41 kDa protein. Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses. Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine. For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4. Also mediates monocyte migration upon CXCL4 binding. 1. Tian, Y. et al. (2004) European journal of immunology 34, 785-795. PMID: 14991608 2. Berahovich, RD. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 174, 7341-51. PMID: 15905581 3. Wei, H. et al. (2024) Cellular signalling 117, 111122. PMID: 38417634 4. Fox, JM. et al. (2018) Scientific reports 8, 9466. PMID: 29930254
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Datasheet

Anti-Human CD191/CCR1 Recombinant Antibody (5908), APC.pdf

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Anti-Human CD191/CCR1 Recombinant Antibody (5908), APC