Anti-Human ENPP-3/CD203c Polyclonal Antibody (HT018014)

Name: Anti-Human ENPP-3/CD203c Polyclonal Antibody
Brand: abinScience
SKU: HT018014
Price: 168 USD
Availability: InStock

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Especificación:

50ug
100ug

Número:

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SDS

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Número de catálogo

HT018014

Descripción

Anti-Human ENPP-3/CD203c Polyclonal Antibody (HT018014) is a rabbit polyclonal antibody detecting ENPP-3/CD203c in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Reactividad de especies

Human

Aplicaciones

ELISA, IHC, WB

Especie huésped

Rabbit

Clonalidad

Polyclonal

Isotipo

IgG

Inmunógeno

E. coli - derived recombinant Human CD203c/ENPP3 (Met640-Pro857).

Objetivo

NPPase, PD-Ibeta, Phosphodiesterase I beta, PDNP3, CD203c, Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, E-NPP 3, ENPP3, NPP3, Phosphodiesterase I/nucleotide pyrophosphatase 3, Nucleotide diphosphatase

Nivel de endotoxinas

Please contact with the lab for this information.

Pureza

>95% as determined by SDS-PAGE.

Purificación

Purified by antigen affinity column.

Número de acceso

O14638

Forma

Liquid

Buffer de almacenamiento

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.

Información de uso del producto

Aplicación	Dilución
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Estabilidad y almacenamiento

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Fondo

Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (CD203c/ENPP3) is a ~100 kDa protein. Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Also hydrolyzes extracellular 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production, and is therefore involved in the regulation of innate immune response. 2',3'-cGAMP appears to be further processed to GMP, AMP and inorganic phosphate. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells.

1. Gorelik, A. et al. (2018) The FEBS journal 285, 2481-2494. PMID: 29717535

2. Jin-Hua, P. et al. (1997) Genomics 45, 412-5. PMID: 9344668

3. Mardjuki, R. et al. (2024) Cell reports 43, 114209. PMID: 38749434

4. Vollmayer, P. et al. (2003) European journal of biochemistry 270, 2971-8. PMID: 12846830

5. Bühring, HJ. et al. (2001) Blood 97, 3303-5. PMID: 11342463

Nota

For research use only.

Imágenes

Referencias

Datasheet

Anti-Human ENPP-3/CD203c Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Proteínas Recombinantes

Anticuerpos

Kits de Ensayo

Anti-Human ENPP-3/CD203c Polyclonal Antibody (HT018014)

Vista general

Imágenes

Referencias

Datasheet

SDS