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| カタログ番号 | HY466014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-Human MDR1/ABCB1 Polyclonal Antibody (HY466014) is a rabbit polyclonal antibody detecting MDR1/ABCB1 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CD243/ABCB1 (Phe394-Val672). | ||||||||
| ターゲット | Phospholipid transporter ABCB1, MDR1, CD243, ATP-binding cassette sub-family B member 1, ABCB1, Multidrug resistance protein 1, P-glycoprotein 1, ATP-dependent translocase ABCB1, PGY1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P08183 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | ATP-dependent translocase ABCB1 (CD243) is a ~141 kDa protein. Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. 1. Choi, KH. et al. (1988) Cell 53, 519-29. PMID: 2897240 2. Masud, SN. et al. (2022) Nature chemical biology 18, 1370-1379. PMID: 35970996 3. van Helvoort, A. et al. (1996) Cell 87, 507-17. PMID: 8898203 4. Chen, G. et al. (1997) The Journal of biological chemistry 272, 5974-82. PMID: 9038218 5. Shafik, SH. et al. (2022) PLoS biology 20, e3001616. PMID: 35507548 | ||||||||
| 注意事項 | For research use only. |
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