Anti-Human CD81 Polyclonal Antibody (HX855014)

Name: Anti-Human CD81 Polyclonal Antibody
Brand: abinScience
SKU: HX855014
Price: 168 USD
Availability: InStock

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Spécification :

50ug
100ug

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SDS

Aperçu

Numéro de catalogue

HX855014

Description

Anti-CD81 Polyclonal Antibody (HX855014) is a rabbit polyclonal antibody detecting CD81 in ELISA, IHC, WB. Suitable for Human, Bovine, Pan troglodytes, and Saguinus oedipus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human CD81 (Phe113-Lys201).

Cible

CD81 antigen, TSPAN28, Target of the antiproliferative antibody 1, Tspan-28, Tetraspanin-28, CD81, TAPA1, 26 kDa cell surface protein TAPA-1

Purification

Purified by antigen affinity column.

Numéro d'accès

P60033

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

CD81 antigen is a ~25 kDa protein. Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/CD3 zeta at antigen-induced synapses with B cells, providing for costimulation and polarization toward T helper type 2 phenotype. Present in MHC class II compartments, may also play a role in antigen presentation.

1. Shoham, T. et al. (2006) Molecular and cellular biology 26, 1373-85. PMID: 16449649

2. van Zelm, MC. et al. (2010) The Journal of clinical investigation 120, 1265-74. PMID: 20237408

3. Zimmerman, B. et al. (2016) Cell 167, 1041-1051.e11. PMID: 27881302

4. Cherukuri, A. et al. (2004) The Journal of biological chemistry 279, 31973-82. PMID: 15161911

5. Sagi, Y. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 1613-8. PMID: 22307619

6. Rocha-Perugini, V. et al. (2013) Molecular and cellular biology 33, 3644-58. PMID: 23858057

7. Secrist, H. et al. (1996) European journal of immunology 26, 1435-42. PMID: 8766544

8. Schick, MR. et al. (1993) Journal of immunology (Baltimore, Md. : 1950) 151, 4090-7. PMID: 8409388

9. Takeda, Y. et al. (2003) The Journal of cell biology 161, 945-56. PMID: 12796480

Note

For research use only.

Images

Reférences

Fiche technique

Anti-Human CD81 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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Kits d'Essai

Anti-Human CD81 Polyclonal Antibody (HX855014)

Aperçu

Images

Reférences

Fiche technique

SDS