Anti-CDK2 Polyclonal Antibody (HB845024)

Name: Anti-CDK2 Polyclonal Antibody
Brand: abinScience
SKU: HB845024
Price: 168 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HB845024

説明

Anti-CDK2 Polyclonal Antibody (HB845024) is a rabbit polyclonal antibody detecting CDK2 in ELISA, IHC, WB. Suitable for Human, Rat, Bovine, Carassius auratus, and Cricetulus griseus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Rat

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human CDK2 (Met1-Leu298).

ターゲット

CDK2, p33 protein kinase, Cyclin-dependent kinase 2, CDKN2, Cell division protein kinase 2

精製

Purified by antigen affinity column.

アクセッション番号

P24941

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Cyclin-dependent kinase 2 (CDK2) is a ~33 kDa protein. Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CABLES1, CTNNB1, CDK2AP2, ERCC6, NBN, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, SUV39H1, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in embryonic stem cells (ESCs).

1. Harbour, JW. et al. (1999) Cell 98, 859-69. PMID: 10499802

2. Luciani, MG. et al. (2000) Journal of molecular biology 300, 503-18. PMID: 10884347

3. Zhao, J. et al. (2000) Genes & development 14, 2283-97. PMID: 10995386

4. Ma, T. et al. (2000) Genes & development 14, 2298-313. PMID: 10995387

5. Okuda, M. et al. (2000) Cell 103, 127-40. PMID: 11051553

6. Garrett, S. et al. (2001) Molecular and cellular biology 21, 88-99. PMID: 11113184

7. Terret, ME. et al. (2003) Development (Cambridge, England) 130, 5169-77. PMID: 12944431

8. Esashi, F. et al. (2005) Nature 434, 598-604. PMID: 15800615

9. Brown, NR. et al. (2007) Cell cycle (Georgetown, Tex.) 6, 1350-9. PMID: 17495531

10. Hydbring, P. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 58-63. PMID: 19966300

注意事項

For research use only.

イメージ

参考文献

データシート

Anti-CDK2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-CDK2 Polyclonal Antibody (HB845024)

概要

イメージ

参考文献

データシート

SDS

クイックアクセス

お問い合わせ