Anti-CFH Polyclonal Antibody (HY505014)

Name: Anti-CFH Polyclonal Antibody
Brand: abinScience
SKU: HY505014
Price: 168 USD
Availability: InStock

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Обзор

Каталожный номер

HY505014

Описание

Anti-CFH Polyclonal Antibody (HY505014) is a rabbit polyclonal antibody detecting CFH in ELISA, IHC, WB. Suitable for Human.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.

Реактивность видов

Human

Применения

ELISA, IHC, WB

Хозяинский вид

Rabbit

Клоональность

Polyclonal

Изотип

IgG

Иммуноген

E. coli - derived recombinant Human CFH (Glu19-Pro346).

Цель

Complement factor H, CFH, H factor 1, HF1, HF, HF2

Очистка

Purified by antigen affinity column.

Номер доступа

P08603

Форма

Liquid

Буфер хранения

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.

Информация об использовании продукта

Применение	Разбавление
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Устойчивость и хранение

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Фон

Complement factor H (CFH) is a ~139 kDa protein. Glycoprotein that plays an essential role in maintaining a well-balanced immune response by modulating complement activation. Acts as a soluble inhibitor of complement, where its binding to self markers such as glycan structures prevents complement activation and amplification on cell surfaces. Accelerates the decay of the complement alternative pathway (AP) C3 convertase C3bBb, thus preventing local formation of more C3b, the central player of the complement amplification loop. As a cofactor of the serine protease factor I, CFH also regulates proteolytic degradation of already-deposited C3b. In addition, mediates several cellular responses through interaction with specific receptors.

1. Kajander, T. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 2897-902. PMID: 21285368

2. Morgan, HP. et al. (2011) Nature structural & molecular biology 18, 463-70. PMID: 21317894

3. Blaum, BS. et al. (2015) Nature chemical biology 11, 77-82. PMID: 25402769

4. Wu, J. et al. (2009) Nature immunology 10, 728-33. PMID: 19503104

5. Kennedy, AT. et al. (2016) Journal of immunology (Baltimore, Md. : 1950) 196, 1239-48. PMID: 26700768

6. Hocking, HG. et al. (2008) The Journal of biological chemistry 283, 9475-87. PMID: 18252712

7. Simon, N. et al. (2013) Cell host & microbe 13, 29-41. PMID: 23332154

8. Xue, X. et al. (2017) Nature structural & molecular biology 24, 643-651. PMID: 28671664

9. Losse, J. et al. (2010) Journal of immunology (Baltimore, Md. : 1950) 184, 912-21. PMID: 20008295

10. DiScipio, RG. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 4057-66. PMID: 9558116

Примечание

For research use only.

Изображения

Ссылки

Даташит

Anti-CFH Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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