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| カタログ番号 | HW574014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CHOP/GADD153/DDIT3 Polyclonal Antibody (HW574014) is a rabbit polyclonal antibody detecting CHOP/GADD153/DDIT3 in ELISA, IHC, WB. Suitable for Human, Mouse.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CHOP/GADD153/DDIT3 (Arg105-Ala169). | ||||||||
| ターゲット | C/EBP-homologous protein, DDIT3, DDIT-3, CCAAT/enhancer-binding protein homologous protein, C/EBP zeta, CHOP-10, Growth arrest and DNA damage-inducible protein GADD153, DNA damage-inducible transcript 3 protein, GADD153, CHOP10, C/EBP-homologous protein 10, CHOP | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P35638 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | DNA damage-inducible transcript 3 protein (CHOP/GADD153) is a ~19 kDa protein. Multifunctional transcription factor in endoplasmic reticulum (ER) stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. 1. Yamaguchi, H. et al. (2004) The Journal of biological chemistry 279, 45495-502. PMID: 15322075 2. Ohoka, N. et al. (2005) The EMBO journal 24, 1243-55. PMID: 15775988 3. Oliveira, SJ. et al. (2009) PloS one 4, e6618. PMID: 19672300 4. Vij, N. et al. (2008) American journal of respiratory cell and molecular biology 38, 176-84. PMID: 17709599 5. Goodall, JC. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 17698-703. PMID: 20876114 6. Ghosh, AP. et al. (2012) PloS one 7, e39586. PMID: 22761832 7. Su, N. et al. (2008) The Journal of biological chemistry 283, 35106-17. PMID: 18940792 8. Park, SH. et al. (2010) The Journal of biological chemistry 285, 35330-9. PMID: 20829347 | ||||||||
| 注意事項 | For research use only. |
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