

| Каталожный номер | HF976014 | ||||||||
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| Описание |
Anti-CLDN1 Polyclonal Antibody (HF976014) is a rabbit polyclonal antibody detecting CLDN1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human CLDN1 (Met1-Val211). | ||||||||
| Цель | CLDN1, Senescence-associated epithelial membrane protein, CLD1, Claudin-1, SEMP1 | ||||||||
| Уровень эндотоксинов | Please contact with the lab for this information. | ||||||||
| Чистота | >95% as determined by SDS-PAGE. | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | O95832 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Claudin-1 (CLDN1) is a ~22 kDa protein. Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. 1. Kirschner, N. et al. (2013) The Journal of investigative dermatology 133, 1161-9. PMID: 23407391 | ||||||||
| Примечание | For research use only. |




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