Anti-Human Claudin-1 Reference Antibody (Lixudebart, RUO) (HF976026)

Name: Anti-Human Claudin-1 Reference Antibody (Lixudebart, RUO)
Brand: abinScience
SKU: HF976026
Price: 176 USD
Availability: InStock

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Overview

Catalog No.	HF976026
Description	Lixudebart (HF976026) is a research-grade recombinant antibody targeting CLDN1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Species reactivity	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host species	Human
Isotype	IgG1-kappa
Expression system	Mammalian cells
Clonality	Monoclonal
Target	CLDN1, Senescence-associated epithelial membrane protein, CLD1, Claudin-1, SEMP1
Endotoxin level	Please contact the lab for this information.
Purity	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	O95832
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	2749515-10-2
Background	Claudin-1 (CLDN1) is a ~22 kDa protein. Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. 1. Kirschner, N. et al. (2013) The Journal of investigative dermatology 133, 1161-9. PMID: 23407391
Note	For research use only. Not suitable for clinical or therapeutic use.

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Anti-Human Claudin-1 Reference Antibody (Lixudebart, RUO).pdf

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Anti-Human Claudin-1 Reference Antibody (Lixudebart, RUO) (HF976026)

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