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| カタログ番号 | HY453014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CLU Polyclonal Antibody (HY453014) is a rabbit polyclonal antibody detecting CLU in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CLU (Ser228-Glu449). | ||||||||
| ターゲット | APOJ, ApoJalpha, NA1/NA2, Complement cytolysis inhibitor, Complement cytolysis inhibitor a chain, Ku70-binding protein 1, Testosterone-repressed prostate message 2, ApoJbeta, TRPM-2, Complement cytolysis inhibitor b chain, SGP-2, KUB1, Apolipoprotein J, Apo-J, Clusterin, Sulfated glycoprotein 2, Aging-associated gene 4 protein, CLI, CLU, Complement-associated protein SP-40, 40 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P10909 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Clusterin (APOJ/SP-40) is a ~52 kDa protein. Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. 1. Poon, S. et al. (2000) Biochemistry 39, 15953-60. PMID: 11123922 2. Wyatt, AR. et al. (2009) The Journal of biological chemistry 284, 21920-21927. PMID: 19535339 3. Poon, S. et al. (2002) The Journal of biological chemistry 277, 39532-40. PMID: 12176985 4. Stewart, EM. et al. (2007) Biochemistry 46, 1412-22. PMID: 17260971 5. Wyatt, AR. et al. (2010) The Journal of biological chemistry 285, 3532-3539. PMID: 19996109 6. Hatters, DM. et al. (2002) European journal of biochemistry 269, 2789-94. PMID: 12047389 7. Kumita, JR. et al. (2007) Journal of molecular biology 369, 157-67. PMID: 17407782 8. Yerbury, JJ. et al. (2007) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21, 2312-22. PMID: 17412999 | ||||||||
| 注意事項 | For research use only. |
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