Protein A/G purified from cell culture supernatant.
Accession
P10909
Form
Liquid
Storage buffer
0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names
16B5, AB-16B52411526-47-9
Background
Clusterin (APOJ/SP-40) is a ~52 kDa protein. Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70.
1. Poon, S. et al. (2000) Biochemistry 39, 15953-60. PMID: 11123922
2. Wyatt, AR. et al. (2009) The Journal of biological chemistry 284, 21920-21927. PMID: 19535339
3. Poon, S. et al. (2002) The Journal of biological chemistry 277, 39532-40. PMID: 12176985
5. Wyatt, AR. et al. (2010) The Journal of biological chemistry 285, 3532-3539. PMID: 19996109
6. Hatters, DM. et al. (2002) European journal of biochemistry 269, 2789-94. PMID: 12047389
7. Kumita, JR. et al. (2007) Journal of molecular biology 369, 157-67. PMID: 17407782
8. Yerbury, JJ. et al. (2007) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 21, 2312-22. PMID: 17412999
Note
For research use only. Not suitable for clinical or therapeutic use.
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