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| カタログ番号 | HW376014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CXCL12/SDF-1 Polyclonal Antibody (HW376014) is a rabbit polyclonal antibody detecting CXCL12 in ELISA, IHC, WB. Suitable for Human, Mouse, and Cat.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CXCL12/SDF-1 (Lys22-Lys89). | ||||||||
| ターゲット | Intercrine reduced in hepatomas, hSDF-1, Stromal cell-derived factor 1, SDF-1, Pre-B cell growth-stimulating factor, SDF1, SDF1A, C-X-C motif chemokine 12, SDF1B, CXCL12, IRH, PBSF, hIRH | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 純度 | >95% as determined by SDS-PAGE. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P48061 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Stromal cell-derived factor 1 (CXCL12/SDF-1) is a ~10 kDa protein. Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for CXCL12/SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. 1. Malik, M. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 4632-7. PMID: 18802065 2. Liu, Y. et al. (2024) Cell reports 43, 114578. PMID: 39093700 3. Oberlin, E. et al. (1996) Nature 382, 833-5. PMID: 8752281 4. Balabanian, K. et al. (2005) The Journal of biological chemistry 280, 35760-6. PMID: 16107333 5. Kalatskaya, I. et al. (2009) Molecular pharmacology 75, 1240-7. PMID: 19255243 6. Fujita, M. et al. (2018) The Biochemical journal 475, 723-732. PMID: 29301984 | ||||||||
| 注意事項 | For research use only. |
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