

| Numéro de catalogue | HY097014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Description |
Anti-CYP21A2 Polyclonal Antibody (HY097014) is a rabbit polyclonal antibody detecting CYP21A2 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Reactivité des espèces | Human | ||||||||
| Applications | ELISA, IHC, WB | ||||||||
| Espèce hôte | Rabbit | ||||||||
| Clonalité | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Immunogène | E. coli - derived recombinant Human CYP21A2 (Leu107-Gly390). | ||||||||
| Cible | CYP21, CYP21B, Cytochrome P450 21, Cytochrome P450-C21B, Cytochrome P450-C21, Cytochrome P450 XXI, 21-OHase, Steroid 21-hydroxylase, Cytochrome P-450c21, CYP21A2 | ||||||||
| Purification | Purified by antigen affinity column. | ||||||||
| Numéro d'accès | P08686 | ||||||||
| Forme | Liquid | ||||||||
| Tampon de stockage | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
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| Informations d'utilisation du produit |
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| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Contexte | Steroid 21-hydroxylase (CYP21A2) is a ~56 kDa protein. A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). 1. Tajima, T. et al. (1999) Gene therapy 6, 1898-903. PMID: 10602386 2. Grischuk, Y. et al. (2006) The Journal of clinical endocrinology and metabolism 91, 4976-80. PMID: 16984992 3. Concolino, P. et al. (2012) Metabolism: clinical and experimental 61, 519-24. PMID: 22014889 4. Pallan, PS. et al. (2015) The Journal of biological chemistry 290, 13128-43. PMID: 25855791 5. de Paula Michelatto, D. et al. (2016) International journal of endocrinology 2016, 4209670. PMID: 27721825 | ||||||||
| Note | For research use only. |
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