中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HY097014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-CYP21A2 Polyclonal Antibody (HY097014) is a rabbit polyclonal antibody detecting CYP21A2 in ELISA, IHC, WB. Suitable for Human.
Highlights
|
||||||||
| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human CYP21A2 (Leu107-Gly390). | ||||||||
| ターゲット | CYP21, CYP21B, Cytochrome P450 21, Cytochrome P450-C21B, Cytochrome P450-C21, Cytochrome P450 XXI, 21-OHase, Steroid 21-hydroxylase, Cytochrome P-450c21, CYP21A2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P08686 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
||||||||
| 製品使用情報 |
| ||||||||
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Steroid 21-hydroxylase (CYP21A2) is a ~56 kDa protein. A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). 1. Tajima, T. et al. (1999) Gene therapy 6, 1898-903. PMID: 10602386 2. Grischuk, Y. et al. (2006) The Journal of clinical endocrinology and metabolism 91, 4976-80. PMID: 16984992 3. Concolino, P. et al. (2012) Metabolism: clinical and experimental 61, 519-24. PMID: 22014889 4. Pallan, PS. et al. (2015) The Journal of biological chemistry 290, 13128-43. PMID: 25855791 5. de Paula Michelatto, D. et al. (2016) International journal of endocrinology 2016, 4209670. PMID: 27721825 | ||||||||
| 注意事項 | For research use only. |
お問い合わせ
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
