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| カタログ番号 | HF506014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-DDAH2 Polyclonal Antibody (HF506014) is a rabbit polyclonal antibody detecting DDAH2 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, and Bovine.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DDAH2 (Ala31-Leu265). | ||||||||
| ターゲット | DDAH, Dimethylargininase-2, NG30, DDAHII, DDAH2, Protein G6a, N(G), N(G)-dimethylarginine dimethylaminohydrolase 2, S-phase protein, G6A, Dimethylarginine dimethylaminohydrolase 2, DDAH-2 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O95865 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Putative hydrolase DDAH2 is a ~29 kDa protein. Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS. In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase. Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein. Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS. 1. Hu, X. et al. (2011) Arteriosclerosis, thrombosis, and vascular biology 31, 1540-6. PMID: 21493890 2. Ragavan, VN. et al. (2023) Nature communications 14, 3392. PMID: 37296100 3. Huang, S. et al. (2021) Science signaling 14. PMID: 33850055 | ||||||||
| 注意事項 | For research use only. |
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