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Anti-DRP1/DNM1L Polyclonal Antibody (HT429014)

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Vista general
Número de catálogoHT429014
Descripción
Anti-DRP1/DNM1L Polyclonal Antibody (HT429014) is a rabbit polyclonal antibody detecting DNM1L in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Danio rerio.
Highlights
  • ●Affinity Purified — Minimal background and high purity for reliable results.
  • ●Multi-Application — Validated across multiple applications.
  • ●Multi-Species — Cross-reactive for translational research.
Reactividad de especiesHuman, Mouse, Rat
AplicacionesELISA, IHC, WB
Especie huéspedRabbit
ClonalidadPolyclonal
IsotipoIgG
Inmunógeno E. coli - derived recombinant Human DRP1/DNM1L (Met1-Arg516).
Objetivo Dynamin family member proline-rich carboxyl-terminal domain less, DVLP, Dynamin-like protein IV, Dynamin-related protein 1, Dynamin-like protein, DLP1, Dymple, Dynamin-1-like protein, HdynIV, Dnm1p/Vps1p-like protein, DRP1, DNM1L, Dynamin-like protein 4
Nivel de endotoxinas Please contact with the lab for this information.
Purificación Purified by antigen affinity column.
Número de acceso O00429
Forma Liquid
Buffer de almacenamiento 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Información de uso del producto
Aplicación Dilución
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Dynamin-1-like protein (DRP1/DNM1L) is a ~81 kDa protein. Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane. Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner.

1. Smirnova, E. et al. (2001) Molecular biology of the cell 12, 2245-56. PMID: 11514614
2. Koch, A. et al. (2003) The Journal of biological chemistry 278, 8597-605. PMID: 12499366
3. Taguchi, N. et al. (2007) The Journal of biological chemistry 282, 11521-9. PMID: 17301055
4. Waterham, HR. et al. (2007) The New England journal of medicine 356, 1736-41. PMID: 17460227
5. Chang, CR. et al. (2007) The Journal of biological chemistry 282, 21583-7. PMID: 17553808
6. Han, XJ. et al. (2008) The Journal of cell biology 182, 573-85. PMID: 18695047
7. Cereghetti, GM. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 15803-8. PMID: 18838687
8. Cho, DH. et al. (2009) Science (New York, N.Y.) 324, 102-5. PMID: 19342591
9. Zunino, R. et al. (2009) The Journal of biological chemistry 284, 17783-95. PMID: 19411255
10. Figueroa-Romero, C. et al. (2009) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 3917-27. PMID: 19638400
Nota For research use only.
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
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Concentration
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Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
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V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
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V₂ (Working Vol.)
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Anti-DRP1/DNM1L Polyclonal Antibody

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