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| カタログ番号 | HT429014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-DRP1/DNM1L Polyclonal Antibody (HT429014) is a rabbit polyclonal antibody detecting DNM1L in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Danio rerio.
Highlights
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| 種反応性 | Human, Mouse, Rat | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human DRP1/DNM1L (Met1-Arg516). | ||||||||
| ターゲット | Dynamin family member proline-rich carboxyl-terminal domain less, DVLP, Dynamin-like protein IV, Dynamin-related protein 1, Dynamin-like protein, DLP1, Dymple, Dynamin-1-like protein, HdynIV, Dnm1p/Vps1p-like protein, DRP1, DNM1L, Dynamin-like protein 4 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O00429 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Dynamin-1-like protein (DRP1/DNM1L) is a ~81 kDa protein. Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane. Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner. 1. Smirnova, E. et al. (2001) Molecular biology of the cell 12, 2245-56. PMID: 11514614 2. Koch, A. et al. (2003) The Journal of biological chemistry 278, 8597-605. PMID: 12499366 3. Taguchi, N. et al. (2007) The Journal of biological chemistry 282, 11521-9. PMID: 17301055 4. Waterham, HR. et al. (2007) The New England journal of medicine 356, 1736-41. PMID: 17460227 5. Chang, CR. et al. (2007) The Journal of biological chemistry 282, 21583-7. PMID: 17553808 6. Han, XJ. et al. (2008) The Journal of cell biology 182, 573-85. PMID: 18695047 7. Cereghetti, GM. et al. (2008) Proceedings of the National Academy of Sciences of the United States of America 105, 15803-8. PMID: 18838687 8. Cho, DH. et al. (2009) Science (New York, N.Y.) 324, 102-5. PMID: 19342591 9. Zunino, R. et al. (2009) The Journal of biological chemistry 284, 17783-95. PMID: 19411255 10. Figueroa-Romero, C. et al. (2009) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 23, 3917-27. PMID: 19638400 | ||||||||
| 注意事項 | For research use only. |
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