

| Каталожный номер | HX082014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Описание |
Anti-E2F1/RBBP3 Polyclonal Antibody (HX082014) is a rabbit polyclonal antibody detecting E2F1/RBBP3 in ELISA, IHC, WB. Suitable for Human.
Highlights
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| Реактивность видов | Human | ||||||||
| Применения | ELISA, IHC, WB | ||||||||
| Хозяинский вид | Rabbit | ||||||||
| Клоональность | Polyclonal | ||||||||
| Изотип | IgG | ||||||||
| Иммуноген | E. coli - derived recombinant Human E2F1/RBBP3 (Val88-Phe437). | ||||||||
| Цель | Retinoblastoma-binding protein 3, Retinoblastoma-associated protein 1, RBBP-3, Transcription factor E2F1, RBBP3, E2F1, E2F-1, RBAP-1, pRB-binding protein E2F-1, PBR3 | ||||||||
| Очистка | Purified by antigen affinity column. | ||||||||
| Номер доступа | Q01094 | ||||||||
| Форма | Liquid | ||||||||
| Буфер хранения | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
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| Информация об использовании продукта |
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| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| Фон | Transcription factor E2F1 (RBBP3) is a ~46 kDa protein. Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. 1. Martínez-Balbás, MA. et al. (2000) The EMBO journal 19, 662-71. PMID: 10675335 2. Stevens, C. et al. (2003) Nature cell biology 5, 401-9. PMID: 12717439 3. García-Alvarez, G. et al. (2007) Biochimica et biophysica acta 1773, 375-82. PMID: 17050006 4. Wang, C. et al. (2007) The Journal of biological chemistry 282, 29902-9. PMID: 17704056 5. Wang, C. et al. (2008) FEBS letters 582, 2793-8. PMID: 18625225 6. Wang, D. et al. (2018) Journal of molecular cell biology 10, 60-73. PMID: 28992046 8. Zaragoza, K. et al. (2010) Molecular and cellular biology 30, 2293-304. PMID: 20176812 | ||||||||
| Примечание | For research use only. |
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