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| カタログ番号 | VK536014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-EBV/HHV-4 BZLF1 Polyclonal Antibody (VK536014) is a rabbit polyclonal antibody detecting BZLF1 in ELISA, IHC, WB.
Highlights
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| 種反応性 | Epstein-Barr virus (HHV-4) (Human herpesvirus 4) | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant EBV/HHV-4 BZLF1 (Leu175-Phe245). | ||||||||
| ターゲット | Lytic switch protein BZLF1, EB1, Protein Z, Trans-activator protein BZLF1, Zta, bZIP transcription factor ZEBRA, BZLF1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | P03206 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Lytic switch protein BZLF1 is a ~26 kDa protein. Transcription factor that acts as a molecular switch to induce the transition from the latent to the lytic or productive phase of the virus cycle (Probable). Mediates the switch from the latent to the lytic cycle of infection in cells containing a highly methylated viral genome. Probably binds to silenced chromatin and recruits host chromatin-remodeling enzymes. Regulates this switch by binding to 2 types of ZEBRA response elements (ZREs): the CpG-free AP-1 like elements (latency) and the methylated CpG-containing elements (lytic replication) (Probable). Activates preferentially the methylated forms of the viral lytic R (BRLF1) and Na (BRRF1) gene promoters, the latters being the first genes activated during Z-mediated reactivation in latently infected cells. 1. Schepers, A. et al. (1993) The EMBO journal 12, 3921-9. PMID: 8404860 2. Bhende, PM. et al. (2004) Nature genetics 36, 1099-104. PMID: 15361873 3. Bernaudat, F. et al. (2022) Nucleic acids research 50, 490-511. PMID: 34893887 4. Schaeffner, M. et al. (2019) Life science alliance 2. PMID: 30926617 5. Flower, K. et al. (2011) PloS one 6, e25922. PMID: 22022468 6. Dickerson, SJ. et al. (2009) PLoS pathogens 5, e1000356. PMID: 19325883 7. Feederle, R. et al. (2000) The EMBO journal 19, 3080-9. PMID: 10856251 | ||||||||
| 注意事項 | For research use only. |
Western blot analysis was performed using anti-BLZF1 polyclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant EBV/HHV-4 BZLF1 (Catalog No: VK536012)
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中国武漢市深敦寺路666号C棟、武漢、430206
